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one had made the slightest advance along the same line until an American dentist renewed the investigation。
In view of the sequel； Davy's experiments merit full attention。 Here is his own account of them； as written in 1799：
〃Immediately after a journey of one hundred and twenty…six miles； in which I had no sleep the preceding night； being much exhausted； I respired seven quarts of nitrous oxide gas for near three minutes。 It produced the usual pleasurable effects and slight muscular motion。 I continued exhilarated for some minutes afterwards； but in half an hour found myself neither more nor less exhausted than before the experiment。 I had a great propensity to sleep。
〃To ascertain with certainty whether the more extensive action of nitrous oxide compatible with life was capable of producing debility； I resolved to breathe the gas for such a time； and in such quantities； as to produce excitement equal in duration and superior in intensity to that occasioned by high intoxication from opium or alcohol。
〃To habituate myself to the excitement； and to carry it on gradually； on December 26th I was enclosed in an air…tight breathing…box； of the capacity of about nine and one…half cubic feet； in the presence of Dr。 Kinglake。 After I had taken a situation in which I could by means of a curved thermometer inserted under the arm； and a stop…watch； ascertain the alterations in my pulse and animal heat； twenty quarts of nitrous oxide were thrown into the box。
〃For three minutes I experienced no alteration in my sensations； though immediately after the introduction of the nitrous oxide the smell and taste of it were very evident。 In four minutes I began to feel a slight glow in the cheeks and a generally diffused warmth over the chest； though the temperature of the box was not quite 50 degrees。 。 。 。 In twenty…five minutes the animal heat was 100 degrees； pulse 124。 In thirty minutes twenty quarts more of gas were introduced。
〃My sensations were now pleasant； I had a generally diffused warmth without the slightest moisture of the skin； a sense of exhilaration similar to that produced by a small dose of wine； and a disposition to muscular motion and to merriment。
〃In three…quarters of an hour the pulse was 104 and the animal heat not 99。5 degrees； the temperature of the chamber 64 degrees。 The pleasurable feelings continued to increase； the pulse became fuller and slower； till in about an hour it was 88； when the animal heat was 99 degrees。 Twenty quarts more of air were admitted。 I had now a great disposition to laugh； luminous points seemed frequently to pass before my eyes； my hearing was certainly more acute； and I felt a pleasant lightness and power of exertion in my muscles。 In a short time the symptoms became stationary； breathing was rather oppressed； and on account of the great desire for action rest was painful。
〃I now came out of the box； having been in precisely an hour and a quarter。 The moment after I began to respire twenty quarts of unmingled nitrous oxide。 A thrilling extending from the chest to the extremities was almost immediately produced。 I felt a sense of tangible extension highly pleasurable in every limb； my visible impressions were dazzling and apparently magnified； I heard distinctly every sound in the room； and was perfectly aware of my situation。 By degrees； as the pleasurable sensations increased； I lost all connection with external things； trains of vivid visible images rapidly passed through my mind and were connected with words in such a manner as to produce perceptions perfectly novel。
〃I existed in a world of newly connected and newly modified ideas。 I theorized； I imagined that I made discoveries。 When I was awakened from this semi…delirious trance by Dr。 Kinglake； who took the bag from my mouth； indignation and pride were the first feelings produced by the sight of persons about me。 My emotions were enthusiastic and sublime； and for a minute I walked about the room perfectly regardless of what was said to me。 As I recovered my former state of mind； I felt an inclination to communicate the discoveries I had made during the experiment。 I endeavored to recall the ideasthey were feeble and indistinct； one collection of terms； however； presented itself； and； with most intense belief and prophetic manner； I exclaimed to Dr。 Kinglake； 'Nothing exists but thoughts！the universe is composed of impressions； ideas； pleasures； and pains。' 〃＇3＇
From this account we see that Davy has anaesthetized himself to a point where consciousness of surroundings was lost； but not past the stage of exhilaration。 Had Dr。 Kinglake allowed the inhaling…bag to remain in Davy's mouth for a few moments longer complete insensibility would have followed。 As it was； Davy appears to have realized that sensibility was dulled； for he adds this illuminative suggestion： 〃As nitrous oxide in its extensive operation appears capable of destroying physical pain； it may probably be used with advantage during surgical operations in which no great effusion of blood takes place。〃＇4＇
Unfortunately no one took advantage of this suggestion at the time； and Davy himself became interested in other fields of science and never returned to his physiological studies； thus barely missing one of the greatest discoveries in the entire field of science。 In the generation that followed no one seems to have thought of putting Davy's suggestion to the test； and the surgeons of Europe had acknowledged with one accord that all hope of finding a means to render operations painless must be utterly abandonedthat the surgeon's knife must ever remain a synonym for slow and indescribable torture。 By an odd coincidence it chanced that Sir Benjamin Brodie； the acknowledged leader of English surgeons； had publicly expressed this as his deliberate though regretted opinion at a time when the quest which he considered futile had already led to the most brilliant success in America； and while the announcement of the discovery； which then had no transatlantic cable to convey it； was actually on its way to the Old World。
The American dentist just referred to； who was； with one exception to be noted presently； the first man in the world to conceive that the administration of a definite drug might render a surgical operation painless and to give the belief application was Dr。 Horace Wells； of Hartford； Connecticut。 The drug with which he experimented was nitrous oxidethe same that Davy had used； the operation that he rendered painless was no more important than the extraction of a toothyet it sufficed to mark a principle； the year of the experiment was 1844。
The experiments of Dr。 Wells； however； though important； were not sufficiently demonstrative to bring the matter prominently to the attention of the medical world。 The drug with which he experimented proved not always reliable； and he himself seems ultimately to have given the matter up； or at least to have relaxed his efforts。 But meantime a friend； to whom he had communicated his belief and expectations； took the matter up； and with unremitting zeal carried forward experiments that were destined to lead to more tangible results。 This friend was another dentist； Dr。 W。 T。 G。 Morton； of Boston； then a young man full of youthful energy and enthusiasm。 He seems to have felt that the drug with which Wells had experimented was not the most practicable one for the purpose； and so for several months he experimented with other allied drugs； until finally he hit upon sulphuric ether； and with this was able to make experiments upon animals； and then upon patients in the dental chair； that seemed to him absolutely demonstrative。
Full of eager enthusiasm； and absolutely confident of his results； he at once went to Dr。 J。 C。 Warren； one of the foremost surgeons of Boston； and asked permission to test his discovery decisively on one of the patients at the Boston Hospital during a severe operation。 The request was granted； the test was made on October 16； 1846； in the presence of several of the foremost surgeons of the city and of a body of medical students。 The patient slept quietly while the surgeon's knife was plied； and awoke to astonished comprehension that the ordeal was over。 The impossible； the miraculous； had been accomplished。＇5＇
Swiftly as steam could carry itslowly enough we should think it to…daythe news was heralded to all the world。 It was received in Europe with incredulity； which vanished before repeated experiments。 Surgeons were loath to believe that ether； a drug that had long held a place in the subordinate armamentarium of the physician； could accomplish such a miracle。 But scepticism vanished before the tests which any surgeon might make； and which surgeons all over the world did make within the next few weeks。 Then there came a lingering outcry from a few surgeons； notably some of the Parisians； that the shock of pain was beneficial to the patient； hence that anaesthesiaas Dr。 Oliver Wendell Holmes had christened the new methodwas a procedure not to be advised。 Then； too； there came a hue…and…cry from many a pulpit that pain was God…given； and hence； on moral grounds； to be clung to rather than renounced。 But the outcry of the antediluvians of both hospital and pulpit quick